Preparation of N-[(imidazopyridinylamino)methylphenyl]carbamates and analogs as gastric acid secretion inhibitors.

Abstract

Title compds. (I; R = Me or CH2OH; R1 = alkyl; R2,R4 = H, halo, alkyl, alkoxy, CF3; R3 = alkoxy; R5 = H, halo, alkyl, alkoxy; Z = O or NH) were prepd. Thus, 8-amino-2-methylimidazo[1,2-a]pyridine-3-carboxaldehyde was N-alkylated by 3,2-Cl(ClH2C)C6H3NHCO2Me and the product reduced to give I (R = CH2OH, R1 = Me, R2 = Cl, R3 = OMe, R4 = R5 = H, Z = NH) which gave 97% inhibition of pentagastrin-induced gastric acid secretion in rats at 6μmol/kg i.v. [on SciFinder(R)]