Preliminary study on the synthesis and high-resolution NMR analysis of Naproxen and Ibuprofen esters

Abstract

The synthesis and NMR analysis of several diastereoisomeric Naproxyl-Naproxenate, Naproxyl-Ibuprofenate and Ibuprofyl-Naproxenate esters are reported. The NMR high resolution spectra run in presence of the chiral shift reagents and variable temperature analysis were done to study the dynamic properties of these esters. Keywords: Anti-inflammatory, ester, NSAID, variable temperature NMR spectroscopy, shift reagent NMR and molecular modelling.