Molecular mechanisms of transcription activation by juvenile hormone: A critical role for bHLH-PAS and nuclear receptor proteins

Abstract

Juvenile hormone (JH) is responsible for controlling many biological processes. In several insect species JH has been implicated as a key regulator of developmental timing, preventing the premature onset of metamorphosis during larval growth periods. However, the molecular basis of JH action is not well-understood. In this review, we highlight recent advances which demonstrate the importance of transcription factors from the bHLH-PAS and nuclear receptor families in mediating the response to JH. © 2012 by the authors; licensee MDPI, Basel, Switzerland.