Conventional and Novel Pharmaceutical Dosage Forms on Prevention of Gastric Ulcers

Abstract

Peptic ulcer formation in either the stomach or duedonum is due to an imbalance between erosive factors such as hydrochloric acid and pepsin and the ability of the gastroduodenal mucosal to protect and heal itself (1). Unlike duedonal ulcers, in which the importance of acid secretion is indisputable, gastric ulcers can develop despite only minimal amounts of acid. On the other hand, it has become apparent that consumption of nonsteroidal antiinflammatory drugs (NSAIDs) and stomach colonization by Helicobacter pylori (H.pylori) are the two most common causes of peptic ulcer disease. The prevention and management of NSAID related gastrointestinal (GI) complications are well recognized and in many cases successfully treated. However, the understanding and treatment of H. pylori-induced ulcers are still in progress (2).