Spectroscopic identification of brominated, non-brominated alkaloids and evaluation of antimicrobial activity of Eudistomin-I, Eudistomin H, from green ascidian Eudistoma viride

Abstract

Several eudistomin groups of compounds were identified from the organic extract of green ascidian Eudistoma viride using MALDI-TOF mass spectrometry. Apart from this, a series of unexplored mass traces belonging to different novel molecules were discovered with and without bromine moiety. The crude extract and its purified fractions were evaluated for the presence of antimicrobial activity against several human pathogenic bacteria. The results suggest that Eudistomin-H and its non-brominated form Eudistomin-I was potentially active against a panel of pathogenic bacteria.