ABO blood type and response of activated partial thromboplastin time to dabigatran in nonvalvular atrial fibrillation patients

Abstract

Background: The association between ABO blood type and the activated partial thromboplastin time (aPTT) under dabigatran therapy in nonvalvular atrial fibrillation (NVAF) patients is unclear. Methods and Results: Between 2011 March and 2015 May, data on ABO blood type and aPTT under dabigatran were obtained for 396 NVAF patients (baseline aPTT, 166). The prevalence of blood type O tended to increase or significantly increase according to baseline aPTT, aPTT under dabigatran, and their difference (ΔaPTT) (P=0.054, 0.001, and 0.012, respectively). Conclusions: In these NVAF patients, a high aPTT value under dabigatran therapy was associated with blood type O.