The Effect of Butterfly Pea Extract on Blood Glucose Levels in White Rats with Metabolic Syndrome Model

Abstract

Introduction: Metabolic syndrome is an accumulation of several disorders, one of which is hyperglycemia. Clitoria ternatea is a plant that contains lots of flavonoids and is known to reduce blood glucose levels in metabolic syndrome. This study aimed to determine the effect of butterfly pea extract ( Clitoria ternatea) on blood glucose levels in white rats with metabolic syndrome models. Methods: This research is an experimental study using animal models with pre and post-test control group design method. The number of samples was 30 male white rats which were divided into 5 groups: group 1–negative control group; group 2–positive control group; group 3, group 4, and group 5 were the metabolic syndrome group which was given Clitoria ternatea extract with doses of 100, 200, and 400 mg/kgBW, respectively for 28 days. Measurement of blood glucose levels for all groups was carried out on the 36 th day as the pre-test and the 64 th day as the post-test. Blood glucose levels were obtained through retroorbital venous blood which was analyzed with the Easy Touch blood glucose stick meter. One-way ANOVA was used to analyze data, followed by post-hoc LSD test, and paired T-test. Results: The average post-test random blood glucose levels decreased by 135.16 mg/dl, 163.18 mg/dl, and 168.35 mg/dl. There was a significant difference (p<0.05) between the pre-test and post-test blood glucose levels along with the average blood glucose level amongst groups. Conclusion: Butterfly pea ( Clitoria ternatea) could decrease blood glucose levels and cause further decrease with higher doses.