Structural, Magnetic and In Vitro Bioactivity of Co-Cu Ferrite and Bioglass Composite for Hyperthermia in Bone Tissue Engineering

Abstract

Magnetic induction hyperthermia is emerging for cancer treatment with bioceramic materials rather radiotherapy and chemotherapy. Copper substituted cobalt ferrites as Co 1-x Cu x Fe 2 O 4 (where x=0.2, 0.4, 0.6, 0.8) ware prepared through self-propagating high-temperature synthesis (SHS) and the effect of copper on the structural, magnetic and biological properties was investigated. XRD revealed the formation of solid solution and the magnetic measurements showed the formation of soft ferrites as compared to CoFe 2 O 4 . The bioactive composite was prepared by incorporating the ferrite having optimum magnetic properties with bioactive glass and the constituent phases in the sintered composite were analyzed by X-ray diffraction (XRD). The bioactive composite comprised of Na 2 Ca 2 Si 3 O 9 phase in solid solution. In vitro bioactivity of the composite was investigated in simulated body fluid (SBF) under physiological conditions. The precipitated hydroxy carbonated apatite (HCA) layer was confirmed by Fourier Transform Infra-Red spectrometer (FTIR), scanning electron microscopy (SEM) and XRD techniques. Cell viability and cytotoxicity against osteoblast MG63cell lines exhibit that the composite is cytocompatible.