Green fabrication of silver nanoparticles using leaf extract of tropical vine Momordica charantia: spectral characterization and in vitro cytotoxicity evaluation on human breast cancer cells

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Abstract

The use of environmental materials such as plant extract for the synthesis of silver nanoparticles (AgNPs) offers numerous benefits of eco-friendliness and compatibility for pharmaceutical and other biomedical Applications. In this study, we used Momordica charantia leaf extract as a reducing agent for the synthesis of AgNPs. Characterization of the AgNPs was done by UV-Visible Spectroscopy, FTIR, SEM, TEM and EDX. Furthermore, we established the in vitro anticancer efficacy of these nanoparticles against the human breast cancer cell line MCF-7 using MTT assay, nuclear morphology testing, and staining. In addition to the above, the anti-bacterial effect was also tested against a range of bacterial isolates using well-diffusion method. These AgNPs also demonstrated impressive results when tested for their free-radical scavenging efficiency on the MCF-7 breast cancer cell line, indicating future potential for their use in medicine. These findings indicated the possible applicability of biosynthesized AgNPs derived from Momordica charantia L.

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Palanisamy, S., David, R., Madav, E., Devi Kannan, V., Rajendran, V., Sampath, S., … Asaithambi, P. (2024). Green fabrication of silver nanoparticles using leaf extract of tropical vine Momordica charantia: spectral characterization and in vitro cytotoxicity evaluation on human breast cancer cells. Materials Technology, 39(1). https://doi.org/10.1080/10667857.2024.2304428

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