One-pot synthesis of substituted 2-amino-3-furonitriles

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Abstract

Solvent-free reaction of substituted a-haloketones with malononitrile in the presence of diethylamine provides an efficient one-pot synthesis of 2-amino-5-aryl (alkyl)-3-furonitriles in high yield.

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Bakavoli, M., Rahimizadeh, M., & Gordi, Z. (2008). One-pot synthesis of substituted 2-amino-3-furonitriles. Journal of Chemical Research, (10), 564–565. https://doi.org/10.3184/030823408X356314

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