Familial occurrence of omphalocele suggesting sex-linked inheritance

Abstract

The occurrence of omphalocele in siblings is rare (McKeown et al., 1953; Irving, 1967; Rothemberg and Barnet, 1974; Rott and Truckenbrodt, 1974) and there is only one report of the presence of this malformation in two generations of a family (Osuna and Lindham, 1976). We report a family in which 4 cases of omphalocele occurred in two generations. Only males were affected, suggesting a sex-linked mode of inheritance.