Abstract
The mutagenic properties of 8 N-nitrosopiperazines were examined in Saccharomyces cerevisiae. Forward mutations to canavanine resistance and reversions of his1-7 were induced by N′-methyl-N-nitrosopiperazine, dinitrosopiperazine, 2-methyldinitrosopiperazine, 2,5-dimethyldinitrosopiperazine, and 2,6-dimethyldinitrosopiperazine, in the presence of rat-liver homogenate. N-nitrosopiperazine, 2,3,5,6-tetramethyldinitrosopiperazine, and 4-benzoyl-3,5-dimethyldinitrosopiperazine were non-mutagenic. © 1980.
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CITATION STYLE
Larimer, F. W., Hardigree, A. A., Lijinsky, W., & Epler, J. L. (1980). Mutagenicity of N-nitrosopiperazine derivatives in Saccharomyces cerevisiae. Mutation Research/Genetic Toxicology, 77(2), 143–148. https://doi.org/10.1016/0165-1218(80)90131-7
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