The synergisim of nucleoside antibiotics combined with guanine 7-n-oxide against a rhabdovirus, infectious hematopoietic necrosis virus (IHNV)

Abstract

Guanine 7-N-oxide was shown to have synergistic activity in combination with neplanocin A against a rhabdovirus, infectious hematopoietic necrosis virus (IHNV), as reported previously. We examined further the antiviral activity of guanine 7-N-oxide in combination with other nucleoside antibiotics against IHNV. Synergism was seen between guanine 7-N-oxide and D-eritadenine or cordycepin. It is considered that compounds inhibiting RNA methylation show synergism with guanine 7-N-oxide. © 1986, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.