Antiprotozoal activities of Vincetoxicum stocksii and Carum copticum

Abstract

The antileishmanial and antimalarial activities of different fractions of Vincetoxicum stocksii, Carum copticum, Gentiana olivierii and Zygophyllum fabago were determined. Amongst these, V. stocksii and C. copticum showed moderate to good antimalarial activity. The ethyl acetate fractions of C. copticum and hexane fraction of V. stocksii showed 94% and 52% inhibition of Plasmodium falciparum (D6 Clone) respectively. The hexane ethyl acetate fraction of C. copticum V. stocksi exhibited antileishmanial activity against, Leishmania donovani promastigotes with IC 50 of 30 μg/mL and 51 μg/mL, respectively.