Pet191 is a cytochrome c oxidase assembly factor in Saccharomyces cerevisiae

Abstract

The twin-Cx9C motif protein Pet191 is essential for cytochrome c oxidase maturation. The motif Cys residues are functionally important and appear to be present in disulfide linkages within a large oligomeric complex associated with the mitochondrial inner membrane. The import of Pet191 differs from that of other twin-Cx9C motif class of proteins in being independent of the Mia40 pathway. Copyright © 2008, American Society for Microbiology. All Rights Reserved.