Enantioselective organocatalytic transfer hydrogenation of α-imino esters by utilization of benzothiazoline as highly efficient reducing agent

Abstract

Benzothiazoline was employed as an efficient and versatile reducing agent for the chiral phosphoric acid-catalyzed transfer hydrogenation of α-imino esters. The corresponding α-amino esters were furnished with excellent enantioselectivities. Novel and readily removable benzothiazolines bearinga hydroxy group were also investigated. © 2010 Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim.