Clinical Outcomes of Catheter-Directed Thrombolysis versus Mechanical Aspiration in Patients with Acute Pulmonary Embolism

Abstract

Purpose: The objective of this study was to evaluate the safety and efficacy of catheter-directed thrombolysis (CDT) and mechanical aspiration (MA) for acute pulmonary embolism (PE). Methods: From February 2022 to October 2024, the clinical data of patients with highand intermediate-risk PE who received endovascular therapy were retrospectively reviewed. Patients were categorized based on the treatment strategy. Results: Fifty-eight consecutive patients were identified. CDT was initiated in 29 patients, while the remaining 29 received MA treatment. The time of thrombolysis and the dosage of urokinase were both lower in the MA group (P <0.05). No differences were found in cardiac biomarkers after 48 hours, perioperative bleeding events, heart/valve injury, and mortality. The total cost of the MA group was much higher compared to CDT alone. The MA group showed better improvement in right ventricular (RV) function with a higher reduction in the right ventricular-to-left ventricular ratio (0.55 ± 0.46 vs. 0.13 ± 0.53, P = 0.017). No differences were found in the reduction of the CT obstruction index. Conclusion: CDT and MA seem to have similar outcomes for patients with acute highand intermediate-risk PE. MA is more effective in improving RV function with less thrombolysis time and fewer thrombolytics.