Synthesis and antimicrobial activity of new glucosamine derivatives

Abstract

In this study, a series of reactions were used to protect and deprotect hydroxyl and amine groups of D-glucosamine which was obtained by the hydrolysis of chitin in concentrated HCl. Amidation of this protected monomer with aromatic and heteroaromatic acids was carried out in dichloromethane in the presence of DCC as a coupling reagent to produce new amides in good yields. Their structures were determined by NMR and MS spectra while their antifungal and antibacterial activities were screened.