The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6

Abstract

Background: Prion protein (PrP) interacts with dipeptidyl aminopeptidase-like protein 6 (DPP6), but the functional significance was unknown. Results: PrP formed complexes with and impacted the function of potassium channels containing DPP6 and Kv4.2. Conclusion: PrP modulates voltage-dependent and kinetic properties of Kv4.2 channels. Significance: This could explain a phenotype of PrP knock-out mice and the effects of amyloid β oligomers. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.