The carbamate esters as organocatalysts in asymmetric Michael addition reactions in aqueous media: When pyrrolidine backbone surpasses 1,2- diaminocyclohexane

Abstract

A pyrrolidine ring containing carbamate ester, pyrrolidine-2-ylmethyl-carbamic acid isobutyl ester has been synthesized. The newly developed pyrrolidine ring containing carbamate ester surpassed 1,2- diaminocyclohexane derived carbamate ester in asymmetric Michael addition reactions in aqueous media providing Michael products with yields (up to 97%), syn diastereoselectivities (up to 97%) and enantioselectivities (up to 94%).