Electrical impedance tomography-guided positive end-expiratory pressure titration for perioperative oxygenation and postoperative pulmonary complications A systematic review and meta-analysis

Abstract

Background: The electrical impedance tomography (EIT)-guided individual positive end-expiratory pressure (PEEP) approach is a noninvasive, radiation-free, and straightforward strategy. However, its validity to prevent postoperative complications remains unclear. To determine whether the EIT-guided PEEP titration in surgery has a higher oxygenation index and lower postoperative complications incidence in patients, we performed a meta-analysis to assess the efficacy. The study design is a systematic review and meta-analysis. Methods: Four databases (Cochrane, PubMed, Web of Science, and Embase) were searched from 2000 to November 2022 for this study. Randomized controlled trials of patients selected for general anesthesia were included. The main indicators of the study were oxygenation and postoperative pulmonary complications. Study quality was assessed using the Cochrane Risk and Bias Tool. Results: A total of 7 articles with 425 subjects were included and were eligible for analysis. Meta-analysis showed that patients had a higher oxygenation index (PaO2/FiO2) after EIT-guided individual PEEP titration compared with other modalities of PEEP titration (6 trials, 351 subjects, standardized mean check = 1.06, 95% confidence interval = 0.59–1.53). For subgroup analysis, the results were still statistically significant both in adult/elder groups and normal/obese groups. No significant advantage was found for the incidence of postoperative pulmonary complications between individual PEEP titration under EIT and other titration strategies (5 trials, 341 subjects, standardized mean check = 0.77, 95% confidence interval = 0.34–1.71). The same results were found in the subgroup analysis. Conclusion: EIT-guided individual PEEP setting significantly improved perioperative oxygenation index compared with other modalities of PEEP ventilation strategies for patients, but no significant differences were found in the incidence of the postoperative pulmonary complications.