Interventions for treating genital chlamydia trachomatis infection in pregnancy

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Background: Chlamydia trachomatis is a sexually transmitted infection. Mother-to-child transmission can occur at the time of birth and may result in ophthalmia neonatorum or pneumonitis in the newborn. Objectives: The objective of this review was to assess the effects of antibiotics in the treatment of genital infection with Chlamydia trachomatis during pregnancy with respect to neonatal and maternal morbidity. Search strategy: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register and added the results to Studies awaiting classification (September 2006). We updated this search on 12 June 2009; no new trial reports identified. Selection criteria: Randomised trials of any antibiotic regimen compared with placebo or no treatment or alternative antibiotic regimens in pregnant women with genital Chlamydia trachomatis infection. Data collection and analysis: Two review authors assessed trial quality and extracted data independently. Study authors were contacted for additional information. Main results: Eleven trials were included. Trial quality was generally good. Amoxycillin appeared to be as effective as erythromycin in achieving microbiological cure (odds ratio 0.54, 95%confidence interval 0.28 to 1.02). Amoxycillin was better tolerated than erythromycin (odds ratio 0.16, 95% confidence interval 0.09 to 0.30). Clindamycin and azithromycin also appear to be effective, although the numbers of women included in trials are small. Authors' conclusions: Amoxycillin appears to be an acceptable alternative therapy for the treatment of genital chlamydial infections in pregnancy when compared with erythromycin. Clindamycin and azithromycin may be considered if erythromycin and amoxycillin are contra-indicated or not tolerated. Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.




Brocklehurst, P., & Rooney, G. (2009). Interventions for treating genital chlamydia trachomatis infection in pregnancy. Cochrane Database of Systematic Reviews. John Wiley and Sons Ltd.

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