Error reduction and parameter optimization of the TAPIR method for fast T1 mapping

Abstract

A methodology is presented for the reduction of both systematic and random errors in T1 determination using TAPIR, a Look-Locker-based fast T1 mapping technique. The relations between various sequence parameters were carefully investigated in order to develop recipes for choosing optimal sequence parameters. Theoretical predictions for the optimal flip angle were verified experimentally. Inversion pulse imperfections were identified as the main source of systematic errors in T1 determination with TAPIR. An effective remedy is demonstrated which includes extension of the measurement protocol to include a special sequence for mapping the inversion efficiency itself. © 2003 Wiley-Liss, Inc.