Rifabutin and Uveitis

Abstract

To the Editor: We report two cases of uveitis associated with rifabutin therapy. A 52-year-old woman with pulmonary Mycobacterium avium complex infection who was negative for the human immunodeficiency virus was referred to our clinic in October 1992 after being treated with several antimicrobial regimens without improvement. With a regimen of clarithromycin, ethambutol, and rifampin, fever and night sweats resolved and cough and dyspnea improved greatly. In May 1993 the patient's respiratory symptoms worsened, and on June 10, 1993, rifampin was discontinued and treatment with rifabutin at a daily dose of 600 mg was initiated. Because of low-grade fever, ciprofloxacin. © 1994, Massachusetts Medical Society. All rights reserved.