Journal Article

The chemistry of N-substituted benzotriazoles. Part 19 [1]. N-alkylation of sulfonamides.

  • Katritzky A
  • Hughes C
Chemica Scripta (1989) 29(1) 27-31
ISSN: 0004-2056
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Abstract

A procedure for the alkylation of sulfonamides with benzotriazole (I) and aldehydes is reported. Thus, PhSO2NH2 was treated with I and Me2CHCHO in PhH or PhMe with azeotropic removal of H2O to give 84% (sulfonamidoalkyl)benzotriazole II. Treating II with NaBH4 in EtOH gave 71% Me2CHCHRNHSO2Ph (III, R = H), whereas, treating II with PhMgBr in THF gave 96% III (R = Ph). [on SciFinder(R)]

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APA

Katritzky, A. R., & Hughes, C. V. (1989). The chemistry of N-substituted benzotriazoles.  Part 19 [1].  N-alkylation of sulfonamides. Chemica Scripta, 29(1), 27–31.

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