Molecular Pathogenesis and the Possible Role of Mitochondrial Heteroplasmy in Thoracic Aortic Aneurysm

3Citations
Citations of this article
6Readers
Mendeley users who have this article in their library.

Abstract

Thoracic aortic aneurysm (TAA) is a life-threatening condition associated with high mortal-ity, in which the aortic wall is deformed due to congenital or age-associated pathological changes. The mechanisms of TAA development remain to be studied in detail, and are the subject of active research. In this review, we describe the morphological changes of the aortic wall in TAA. We outline the genetic disorders associated with aortic enlargement and discuss the potential role of mitochondrial pathology, in particular mitochondrial DNA heteroplasmy, in the disease pathogenesis.

References Powered by Scopus

Reactive oxygen species in inflammation and tissue injury

3478Citations
N/AReaders
Get full text

Chemokines: A new classification system and their role in immunity

3446Citations
N/AReaders
Get full text

The International Registry of Acute Aortic Dissection (IRAD): New insights into an old disease

3075Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Mitochondrial ribosomal protein genes connected with Alzheimer's and tellurite toxicity

11Citations
N/AReaders
Get full text

A yeast based assay establishes the pathogenicity of novel missense ACTA2 variants associated with aortic aneurysms

1Citations
N/AReaders
Get full text

Calciprotein particles induce arterial stiffening ex vivo and impair vascular cell function

0Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Suslov, A. V., Afanasyev, M. A., Degtyarev, P. A., Chumachenko, P. V., Ekta, M. B., Sukhorukov, V. N., … Postnov, A. Y. (2021, December 1). Molecular Pathogenesis and the Possible Role of Mitochondrial Heteroplasmy in Thoracic Aortic Aneurysm. Life. MDPI. https://doi.org/10.3390/life11121395

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 1

100%

Readers' Discipline

Tooltip

Medicine and Dentistry 2

67%

Immunology and Microbiology 1

33%

Save time finding and organizing research with Mendeley

Sign up for free