CVm6A: A visualization and exploration database for m6 as in cell lines

Abstract

N6-methyladenosine (m6 A) has been identified in various biological processes and plays important regulatory functions in diverse cells. However, there is still no visualization database for exploring global m6 A patterns across cell lines. Here we collected all available MeRIP-Seq and m6 A-CLIP-Seq datasets from public databases and identified 340,950 and 179,201 m6 A peaks dependent on 23 human and eight mouse cell lines respectively. Those m6 A peaks were further classified into mRNA and lncRNA groups. To better understand the potential function of m6 A, we then mapped m6 A peaks in different subcellular components and gene regions. Among those human m6 A modification, 190,050 and 150,900 peaks were identified in cancer and non-cancer cells, respectively. Finally, all results were integrated and imported into a visualized cell-dependent m6 A database CVm6A. We believe the specificity of CVm6A could significantly contribute to the research for the function and regulation of cell-dependent m6 A modification in disease and development.