Synthesis of some novel imidazolidine derivatives and their metal complexes with biological and antitumor activity

Abstract

Halogenated imidazo(pyrazine,[1,4]-diazocine and quinoxaline), 9,10-anthraquinone-[6,7-e], phenanthroline[5,6-e] {imidazo[4,5-b]-pyrazine}, and naphtho[1,8-ef]imidazo[4,5-b][1,4] diazipen were obtained through interaction of imidazolidineiminothiones with the corresponding diamino compounds. Imidazo[4,5-e] triazine and pyrrolo[2,3-d]imidazole were prepared when the iminothiones were reacted with thiocarbohydrazide and with ethylphenyl acetate, separately. Some of the synthesized compounds exhibited better biological and antitumor activities. © 2006 Wiley Periodicals, Inc.