Production of a new type of amidepsine with a sugar moiety by static fermentation of Humicola sp. FO-2942

Abstract

Static fermentation of amidepsine-producing fungus Humicola sp. FO-2942 led to the production of six new amidepsines, including a new type of glycosylated congener. Non-glycosylated amidepsine J inhibited both human diacylglycerol acyltransferases 1 (DGAT1) and DGAT2 with the same IC50 value of 40 μM, whereas glycosylated amidepsines F to I howed very weak inhibitory activity against DGAT1 and DGAT2. © 2010 Japan Antibiotics Research Association.