Magnetic resonance imaging deformation-based segmentation of the hippocampus in patients with mesial temporal sclerosis and temporal lobe epilepsy

Abstract

The manual and automated segmentations of the hippocampus in patients with mesial temporal sclerosis were compared. An electronic atlas of the hippocampus is used as a deformable template, which is matched to an individual magnetic resonance image to extract and study the hippocampal areas. The deformation-based hippocampal segmentations for patients with mesial temporal sclerosis provide an efficient, precise, and reproducible method of hippocampal volume measurement.