Effect of traditional Chinese medicine treatment on levels of blocking antibody, beta-hCG, progesterone and estradiol in spontaneous abortion

Abstract

OBJECTIVE: To explore the effect of traditional Chinese medicine (TCM) on abnormal maternal-fetal immune and endocrine in 24 cases of threatened abortion (TA) and 68 cases of recurrent spontaneous abortion (RSA). METHODS: The levels of blocking effect (BE), antiidiotype antibody (AIA), cytotoxin antibody (CTA), beta-human chorionic gonadotropin (beta-hCG), progesterone (P), estradiol (E2) were measured in all 92 patients. RESULTS: Incidence rates of the lack of BE, AIA and CTA in 92 cases were 60.87%, 57.61% and 72.83% respectively. The lower levels of BE, AIA and CTA were elevated significantly (P < 0.05-0.01), and the serial levels of beta-hCG, P and E2 were markedly increasing (P < 0.01) in all successful pregnant patients. The rate of the successful pregnancy of 92 cases was 89.13% (to TA 91.67%, to RSA 88.24% respectively). CONCLUSIONS: It suggests that the lack of blocking antibody (BA) and endocrine hormone deficiency may result in spontaneous abortion during early pregnancy. The therapeutic mechanism of those herbs in treating spontaneous abortion was associated with the growing levels of BA and hormone by regulating the maternal-fetal immunity and endocrine.