Transfer hydrogenation of imines with carboxyl-tailed benzothiazoline as readily removable hydrogen donor

Abstract

A benzothiazoline bearing 4-carboxyphenyl group at 2-position was developed as an efficient hydrogen donor for the transfer hydrogenation reaction. Introduction of the carboxyl group significantly facilitated the removal of the residual benzothiazoline and benzothiazole by washing with aqueous basic solution. The present approach provides a convenient and straightforward access to various amines with broad substrate scope and in good yields. © 2011 Elsevier Ltd. All rights reserved.