A Three-component Cascade Cyclization to Construct 3-(2-Oxopropyl)-2-arylisoindolinone Derivatives via Copper-catalyzed Annulation

Abstract

An efficient synthesis of a variety of poly-substituted isoindolinone derivatives via copper-catalyzed three-component cascade cyclization among 2-formylbenzonitriles, alkyl aryl ketones/prop-1-en-2-ylbenzene and diaryliodonium salts is achieved. Various isoindolinone derivatives could be obtained in good to excellent yields. A concise synthesis of dihydroisoindolo[2,1-a]quinolin-11(5H)-ones have been achieved using this method. (Figure presented.).