Three novel sesquiterpene glycosides of Sarcandra glabra

Abstract

Three new sesquiterpene glycosides, 8β,9β-epoxy-4α-hydroxy- 5αH-lindan-7(11)-en-8α,12-olide-15-O-β-D-glucopyranoside (1, sarcaglaboside F), 4a-hydroxy-5α,8βH-lindan-7(11)-en-8α,12- olide-15-O-β-D-glucopyra-noside (2, sarcaglaboside G), 4α-hydroxy- 5α,8βH-eudesman-7(11)-en-8α,12-olide-15-O-β-D- glucopyranoside (3, sarcaglaboside H), together with five known compounds, chloranoside A (4), sarcaglaboside C (5), dihydrovomi-foliol-O-β-D- glucopyranoside (6), 9-hydroxy-heterogorgiolide (7) and chloranthalactone B (8), were isolated from Sarcandra glabra Thumb. Nakai. The structures and relative configurations of three new compounds were determined on the basis of their spectroscopic data and chemical evidence. © 2009 Pharmaceutical Society of Japan.