Prediction of creatinine clearance from serum creatinine in spinal cord injury patients

Abstract

Measured endogenous creatinine clearance (Ccr) was compared with the predicted Ccr in 22 paraplegic, 36 tetraplegic and 11 ambulatory male individuals as well as ii ambulatory females all of whom had normal renal function. While the predicted and measured values closely matched in the ambulatory patients the predicted values in the spinal cord injured patients consistently exceeded the measured values. It thus appears that the original Cockcroft and Gault formula; [Formula Presented] when applied to SCI patients can be misleading. Modification of the orginal formula using a correction factor of 0.8 in paraplegice and 0.6 in tetraplegice was found to alloow prediction of Ccr from age, sex, body weight, and serum creatinine in these patients with reasonable accuracy. © 1983 International Medical Society of Paraplegia.