Synthesis and biological evaluation of some 3b-hydroxy-lup-20(29)-en-28-oic acid derivatives

Abstract

Objective: The present study projected to the synthesis of 3b-Hydroxy-lup-20(29)-en-28-oic acid analogues in order to evaluate their possible biological activity. In addition, the structure-activity relationship is also investigated. Method: BA derivatives were prepared by conjugating 3b-Hydroxy-lup-20(29)-en-28-oic acid with different amines through carbomyl linkage. Structures of synthesized compounds were elucidated by spectral data. Cytotoxic evaluation was done by CAM assay and MTT assay. Results: Among the synthesized compounds, Compound 7showed a pronounced cytotoxicity in antiangiogenic assay as well as compound ECV-304 cell line. Compound 10 also showed good cytotoxic activity. While compounds 6 and 8 showed moderate activity against A-549 and MCF-7 respectively. Conclusion: It is concluded that synthesized BA analogues are biologically active and developed into useful anticancer agents.