Clinical features, prognosis, and influencing factors of contralateral prophylactic mastectomy in 58 patients with breast cancer

Abstract

Background: The past two decades have witnessed the increasing application of contralateral prophylactic mastectomy (CPM) for women with breast cancer in the western countries. Over 30% of young patients choose to underwent CPM up to 2015. However, the adoption rate of CPM has not shown a remarkably increasing in Asian countries. In China, only a few centers have introduced CPM, and no relevant literature has been published. In this study, we look forward to identify the clinical features and prognostic factors of women who underwent CPM in our hospital, to inform decision-making processes for both doctors and patients. Method(s): The clinical data of 58 eligible patients were retrospectively analyzed. Intergroup comparisons were based on independent samples t-test and chi square test. The 5-year disease-free survival (DFS) and overall survival (OS) were obtained by using life tables, and factors affecting the survivals were analyzed by using the Kaplan-Meier method. Result(s): The mean age of these women was 40.14+/-11.17 years, with 30 patients (51.7%) being 0.05). Kaplan-Meier survival analysis and log rank test further confirmed the above findings. Conclusion(s): The majority of patients who choose CPM are young and with known risk factors for breast cancer. Part of the young patients (