A microcapsule self-regulating delivery for insulin

Abstract

Hydrophilic nylon microcapsules containing con canavalin A and succiny1-amidophenyl-glucopyr anoside insulin (SAPG-insulin), whose average diameter was 70 μm were prepared to achieve a self-regulating insulin delivery system. The mi crocapsules were enclosed in polymer membranes for in vitro assessment and the release of SAPG-insulin was evaluated under a flow condition of glucose solution. The amount and the rate of SAPG-insulin released from this pouch were dependent upon the external glucose concentration around the pouch. Also, SAPG-insulin was quickly released from a pouch in response to the change of the external glucose concentration. In addition, to optimize this self regulating insulin delivery system, we studied the kinetics of solute permeation through a membrane separating two compartments : donor and receiver under the condition that the receiver compartment was continuoustly eluted. © 1992, THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM. All rights reserved.