Tractography-based of quantitation of diffusion tensor imaging parameters in white matter tracts of preterm newborns

Abstract

Purpose: To evaluate the feasibility of performing diffusion tensor tractography (DTT) to map and quantify the pyramidal white matter tracts of premature newborns. Materials and Methods: Fourteen diffusion tensor MRI (DTI) examinations of nine premature newboms were evaluated. DTT was performed to segment bilateral pyramidal tracts, using a fiber-tracking algorithm originating in the cerebral peduncle (CP) and filtering through the posterior limb of the internal capsule (PLIC) and precentral gyrus (PCG). Voxels containing the resulting tracts were then used for quantitatlon of DTI parameters along the tract. The DTT-based tract measurements were compared with standard manually placed region-of-interest (ROI) measurements at four locations along the pyramidal tract, and the reproducibility of each technique was evaluated. Results: DTT demonstrated improved reproducibility over manual ROI measurement for pyramidal tract quantitation and was less subject to Ultra-operator variability (P < 0.0001, Fisher test for equal variance). In general, the anatomic locations and measurements obtained with the two techniques were in good agreement, although some systematic differences were identified in the PLIC and CP. Conclusion: Fiber DTT is feasible in premature newboms, provides more reproducible tract measurements than manual ROI methods, and allows quantitation along the entire tract for more detailed DTI assessment of white matter maturation. © 2005 Wiley-Liss, Inc.