Rhamnosyltransferase genes migA and wapR are regulated in a differential manner to modulate the quantities of core oligosaccharide glycoforms produced by Pseudomonas aeruginosa

Abstract

migA and wapR are rhamnosyltransferase genes involved in the biosynthesis of Pseudomonas aeruginosa lipopolysaccharide core oligosaccharide. Here, we show that preferential expression of migA and wapR correlated with the levels of uncapped and O polysaccharide-capped core, respectively. wapR is negatively regulated, while migA is positively regulated by RhlR/RhlI quorum sensing. © 2012, American Society for Microbiology.