Risk factors for renal survival in chinese patients with myeloperoxidase-ANCA-associated GN

Abstract

Background and objectives Our study explored the association of histopathologic classification of ANCA-associated GN with renal survival in Chinese patients with myeloperoxidase-ANCA–associated GN. Design, setting, participants, & measurements Two hundred fifteen patients with biopsy-proven myeloperoxidase-ANCA–associated GN were included from January of 1996 to December of 2014. The biopsies included focal (n=27), mixed (n=82), crescentic (n=47), and sclerotic (n=59) classes. The long-term renal outcome and risk factors of myeloperoxidase-ANCA–associated GN for different histopathologic classes were retrospectively analyzed. Results During a median follow-up time of 22 (9–51) months, 88 (40.9%) patients reached ESRD. The 5-year renal survival (overall 58.7%) was highest in the focal class (100.0%) and lowest in the sclerotic class (20.7%), with no difference between the mixed (58.9%) and crescentic (67.4%) classes. Patients in the mixed (hazard ratio, 0.34; 95% confidence interval, 0.20 to 0.57; P,0.001) and crescentic (hazard ratio, 0.31; 95% confidence interval, 0.16 to 0.59; P,0.001) classes were at lower risk for ESRD compared with patients in the sclerotic class, as were patients who received glucocorticoids plus mycophenolate mofetil (hazard ratio, 0.32; 95% confidence interval, 0.18 to 0.60; P,0.001) compared with those receiving glucocorticoids alone. In addition, patients with a serum creatinine level ․4 mg/dl (hazard ratio, 2.93; 95% confidence interval, 1.77 to 4.85; P,0.001) or hypoalbuminemia (hazard ratio, 2.11; 95% confidence interval, 1.32 to 3.34; P=0.002) were at higher risk for ESRD. A serum creatinine level ․4 mg/dl and a percentage of global sclerotic glomeruli ․60% were the two independent risk factors for ESRD in the sclerotic class. Conclusions The histopathologic classification of ANCA-associated GN in combination with serum creatinine and serum albumin levels and treatment regimen is associated with renal outcome in myeloperoxidase-ANCA–associated GN. The evaluation of serum creatinine level and percentage of global sclerotic glomeruli provides additional information on the risk of renal survival in the sclerotic class of myeloperoxidase-ANCA–associated GN.