α-C-H Photoalkylation of a Glucose Derivative in Continuous Flow

Abstract

Site-selective photoalkylation is a powerful strategy to extend the carbon framework of carbohydrates, otherwise often attainable only through laborious syntheses. This work describes the adaptation and upscaling of the photoalkylation of a glucose derivative as a continuous flow process. The reported iridium catalyst is replaced by an organic sensitizer and the reaction has been carried out on 40-gram scale.