Head space GC/MS analysis of volatile constituents of Trichilea connaroides wight and Arn. Extracts and their in vitro anti-plasmodium activity against plasmodium falciparum isolates

Abstract

Head space GC-MS analysis ethyl acetate extracts of leaves, bark, root and pericarps of Trichilia connnaroides Wight and Arn. Revealed the presence of over 45 compounds of which 22.06, 97.24, 46.42 and 58.27% of the total volatiles from extracts of leaves bark, root and pericarps were identified, respectively. The volatile constituents of bark extract were rich in sesquiterpenoides. Copaene (24.71%), azulene (17.47%), α-cubebene (14.98%), β-cadinene (12.58%), α-bergamotene (4.96%) and ylangene (5.50%) were the major constituents of the total volatiles of the extract. The identified constituents in other extract were 22.06% in leaves extract, 46.42% in root extract and 58.26% in pericarp extract, respectively. In vitro antiplasmodium activity of five extract were tested against K 1 strain of Plasmodium falciparum isolates. All the extract showed antiplasmodial activity. Relatively high activity was observed in dichloromethane extract. © 2011 Academic Journals Inc.