The Combination of Photothermal Therapy and Chemotherapy using Alginate-Modified Iron Oxide-Gold Nanohybrids Carrying Cisplatin

Abstract

Background: Chemotherapy is typically the first-line treatment for the advanced stage of cancers. However, there are shortcomings with respect to conventional chemotherapy that limit therapeutic efficiency, including lack of tumor selectivity, sys-temic toxicity and drug resistance. Objective: A multifunctional nanoplatform was build using of hydrogel co-loaded containing cisplatin and Iron oxide–gold core-shell nanoparticles. The Au shell com-prises the light response and the iron core can be utilized as a negative contrast agent in nanocomplex. Material and Methods: In this experimental study, KB cells derived from the epithelial cells located in the nasopharynx were exposed to different levels of concentration of hydrogel co-loaded with cisplatin and Iron oxide–gold core-shell nanoparticles. Afterwards, the cytotoxicity was determined using MTT assay. Results: The cytotoxicity results showed that this nanoplatforms has potent to cre-ate higher cytotoxicity in KB cells than free cisplatin, so that Fe-Au@Alg and Fe-Au@ Alg with cisplatin mixed with laser irradiation exhibited a significant reduction in cell viability after 5 min. Conclusion: Hydrogel co-loaded with cisplatin and Iron oxide–gold core–shell nanoparticles are stable construct to combine chemo-photothermal therapy. Therefore, they can be used as a computed tomography-traceable nanocarrie, enabling us to moni-tor the delivery of therapeutics.