Abstract
Two novel angucyclinone-type antibiotics, simocyclinones D4 and D8, were detected in the mycelium extract of Streptomyces antibioticus Tu 6040 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The compounds show antibiotic activities against Gram-positive bacteria and cytostatic effects on various tumor cell lines.
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CITATION STYLE
Schimana, J., Fiedler, H. P., Groth, I., Submuth, R., Beil, W., Walker, M., & Zeeck, A. (2000). Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tu 6040. I. Taxonomy, fermentation, isolation and biological activities. Journal of Antibiotics, 53(8), 779–787. https://doi.org/10.7164/antibiotics.53.779
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