Direct synthesis of (+)-erogorgiaene through a kinetic enantiodifferentiating step

Abstract

(Chemical Equation Presented) The combined approach of C-H activation and a Cope rearrangement catalyzed by a rhodium catalyst [Rh2(R-dosp) 4] (dosp = (N-dodecylbenzenesulfonyl)prolinate) is shown to be a very effective method for the construction of the three stereogenic centers (marked in red, see scheme) present in the diterpene erogorgiaene (1). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.