p-Alkoxybenzyl Alcohol Resin and p-Alkoxybenzyloxycarbonylhydrazide Resin for Solid Phase Synthesis of Protected Peptide Fragments

Abstract

Two new resins—p-alkoxybenzyl alcohol resin (HOCH2C6H4OCH2C6H4 resin) and p-alkoxybenzyloxycarbonylhydrazide resin (H2NNHCOOCH2C6H4OCH2C6H4 resin)—were prepared. The former resin is suitable for the synthesis of protected peptide fragments possessing a free carboxyl group while the latter is useful for the synthesis of protected peptide hydrazides. Applications of these resins in the syntheses of Z-Leu-Leu-Val-Phe, Z-Phe-Val-Ala-Leu-HNNH2, Asp-Arg-Val-Tyr-Val-His-Pro-Phe, Z-Lys(Z)-Phe-Phe-Gly, and Z-Lys(Z)-Phe-Phe-Gly-Leu-Met-NH2are described. © 1973, American Chemical Society. All rights reserved.