Abstract
Mallery et al. demonstrate that HIV is crucially dependent upon the host metabolite IP6 to produce infectious virions. Cells deficient in IP6 produce fewer virions, while virions that fail to package sufficient numbers of IP6 molecules are poorly infectious and fail to replicate in primary cells.
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CITATION STYLE
APA
Mallery, D. L., Faysal, K. M. R., Kleinpeter, A., Wilson, M. S. C., Vaysburd, M., Fletcher, A. J., … James, L. C. (2019). Cellular IP6 Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP6 Are Attenuated for Infection and Replication. Cell Reports, 29(12), 3983-3996.e4. https://doi.org/10.1016/j.celrep.2019.11.050
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