Effects of perinatal combined exposure to 1,1-dichloro-2,2 bis (p-chlorophenyl) ethylene and tributyltin on male reproductive system

Abstract

Prenatal or early postnatal exposure to some synthetic chemicals may affect the later reproductive system of the offspring. There may also be unique responses observed due to exposure to combinations of chemicals that are not observed when the chemicals are present individually. 1,1-Dichloro-2,2 bis (p-chlorophenyl) ethylene (p,p′-DDE) is a persistent metabolite of DDT and tributyltin (TBT) compounds are used primarily as antifouling agents, as they exert biocidal actions. p,p′-DDE and TBT are ubiquitously distributed in the environment. Oral p,p′-DDE and TBT intake through marine products is demonstrated to be high in Japan. Consequently, the foetus and neonate are supposed to be exposed much more to p,p′-DDE and TBT via the maternal body. Therefore, effects of perinatal exposure to p,p′-DDE and/or TBT on the reproductive system after maturation have been investigated in rat male offspring of dams orally administered 125 ppm p,p′-DDE (approximately 10 mg/kg) and 25 ppm TBT (approximately 2 mg/kg) during the gestational and lactational period. In this study, growth retardation attributed to TBT has sustained in rat male offspring after perinatal exposure. However, perinatal exposure to p,p′-DDE and TBT failed to affect the male reproductive organs and sperm parameters in matured male offspring. © Basic & Clinical Pharmacology & Toxicology 2006. All rights reserved.