Regenerative Endodontics (Revitalization/Revascularization)

Abstract

This chapter talks about regenerative endodontics. The potential for revascularization of the pulp space with functional tissue capable of hard tissue deposition after such dental trauma has been well-documented in the literature. A number of case reports present evidence of revascularization of replanted immature teeth, with reports of continued root thickening and apical closure, sensitivity to thermal stimulus and electrical pulp testing, and normal laser Doppler flowmetry readings. Zuong and associates compared root development and periapical healing between revitalization and apexification of immature dog teeth after inducing periapical periodontitis. Three components have been mentioned in the literature to contribute to the success of revitalization procedures. They include stem cells that are capable of hard tissue formation, a three-dimensional physical scaffold that can support differentiation and growth of cells and finally signaling molecules for cellular stimulation, proliferation, and differentiation.